28 days ago


Paul Scherrer Institut

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The Paul Scherrer Institute PSI is the largest research institute for natural and engineering sciences within Switzerland. We perform cutting-edge research in the fields of matter and materials, energy and environment and human health. By performing fundamental and applied research, we work on sustainable solutions for major challenges facing society, science and economy. PSI is committed to the training of future generations. Therefore about one quarter of our staff are post-docs, post-graduates or apprentices. Altogether PSI employs 2100 people.


At PSI our team is located at the Center for Radiopharmaceutical Sciences and we are engaged in the development of well-defined antibody-drug conjugates (ADCs) for therapeutic and/or diagnostic applications. By conjugating antibodies with therapeutic molecules (drugs) to create antibody-drug conjugates (ADCs), the drugs can be delivered in a targeted manner, i.e. directly and specifically to the diseased tissue within the human body avoiding healthy cells. In our Laboratory we have now developed a new proprietary technology platform to conjugate the drug (or payload) to the antibody using enzymes. This technology platform will now be commercialized through a start-up from PSI that is currently in foundation.


To further develop the technology and to strengthen our team we are looking for a


with strong skills in interdisciplinary projects

  • Enzymatic preparation of antibody-drug conjugates and their characterization using various analytical tools including mass spectrometry, size exclusion chromatography etc.
  • Determine the in-vitro stability of prepared ADCs using suitable assays
  • Perform and evaluate in-vitro cell toxicity studies using suitable cell-lines
  • Determine the pharmacokinetic and therapeutic properties of the ADCs by radiolabeling
  • Contribute to writing of project and grant proposals and patents
  • Degree in Life Sciences (e.g. pharmaceutical sciences, biochemistry, biomedical engineering or similar) with a solid understanding of protein engineering
  • Several years working experience in pharmaceutical/biotech industry will be a significant plus
  • Significant working experience with therapeutic proteins and protein analysis tools (size-exclusion chromatography, hydrophobic interaction chromatography, mass spectrometry etc.)
  • Experience in performing cell-culture assays to determine toxicity values of drug compounds
  • Experience in performing pharmacokinetic and therapeutic studies of drug compounds in small animal handling permit would be a plus
  • Previous working experience with antibodies and/or antibody-drug conjugates will be a strong asset
  • Ability to work independently in an interdisciplinary group
  • Fluent English speaking and ideally knowledge in German

Our institution is based on an interdisciplinary, innovative and dynamic collaboration. You will profit from a systematic training on the job, in addition to personal development possibilities and our pronounced vocational training culture. If you wish to optimally combine work and family life or other personal interests, we are able to support you with our modern employment conditions and the on-site infrastructure.


The employment contract will (initially) be limited to 1 year. After one year, there is a possibility to join the company and the unique chance to shape a biotech start-up developing a next-generation technology platform from its very beginning is given. This includes hands-on experience in building-up of a state-of-the art laboratory.

For further information please contact Dr Martin Behe, phone +41 56 310 28 17.


Please submit your application online (including list of publications and addresses of referees) for the position as a Scientist (index no. 2222-00).

Paul Scherrer Institut
Sevil Minniti
5232 Villigen PSI