In Roche's Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world's toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.
This position is located in ADME, a chapter within Global Pharmaceutical Sciences, where the fate of new chemical entities and biologics is a primary focus.
The ADME Chapter works throughout all stages of compound development, from lead optimization to candidate selection, all clinical development phases, to the filing of new drug applications. We closely collaborate with our therapeutic areas and functions to convert hypotheses into innovative therapeutics.
Plasma Protein binding (PB) affects both pharmacokinetic (PK) and pharmacodynamic (PD) properties of drugs and influences drug absorption, distribution, metabolism, and excretion (ADME) properties. Therefore, determining the protein binding in the early stages of drug discovery and development is of great importance. The Plasma Protein Binding Scientist will ensure the accurate and reliable determination of protein binding to support new research and development of drug candidates.
You set up, validate and apply state-of-the-art methodologies to assess the binding of our new drug candidates focusing on the accurate and reliable determination of unbound fraction to support compound progression supporting dose estimations for both preclinical and support clinical studies.
You actively contribute to projects at different stages, from early discovery up to regulatory submission. You will develop and communicate experimental strategies, document results and communicate with the different stakeholders.
You support clinical programs for therapeutic drug monitoring.
The development of new, innovative in vitro tools and approaches to addressing questions related to the binding of new modalities are equally part of this job to assure implementation of the best at Roche.
You hold a PhD in biochemistry, pharmacokinetics or related relevant discipline with in-depth knowledge and several years of practical experience (preferably industrial) in the area of Plasma Protein Binding research.
You are familiar with common digital tools for experimental planning, FAIR data capturing, evaluation and reporting in databases and reports.
Preferably you gained hands-on experience with quantitative LC-mass spectrometry and in silico prediction methodologies (e.g. PBPK). Therapeutic Drug Monitoring Clinical study experience would be advantageous.
You are committed to working in a team and are focused to drive the portfolio forward with the best approaches available.
Roche commits to recognising talent and aptitude. We prioritize encouraging and supporting our employees in their personal journeys by providing a safe, creative space to help them reflect, make decisions and grow in their career.
We are confident that we find the most innovative solutions by gaining different perspectives, asking and answering hard questions, and challenging the status quo.
Roche embraces diversity and equal opportunity in a serious yet enthusiastic way; we are devoted to building a team that represents a range of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.
Who we are
At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we've become one of the world's leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.
Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.
Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.
We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.
Roche is an Equal Opportunity Employer.