The Roche Innovation Center Zurich (Roche Glycart AG) is active in the research and development of engineered therapeutic antibodies, with a focus on the fields of cancer immunotherapy.Part of the Roche Group since 2005, it currently employs about 140 people.
Roche is an equal opportunity employer.
With Roche’s growing portfolio of novel biotherapeutic modalities we are looking for a highly motivated and experienced scientist in the area of preclinical Immunology within Pharmaceutical Sciences.
As the successful applicant you will:
Work on the identification, mechanistic understanding and mitigation of effects of mainly biotherapeutics on the immune system from the target assessment phase up to and beyond marketing authorization
Have close interaction with a multitude of functions in Discovery, Pharmaceutical Sciences and Clinical Development
Represent the Immunopathology section in portfolio projects in immunology/immunopathology- related questions in close collaboration with other functions
Assess targets, identify relevant immunobiomarkers and suitable animal model
Ensure translatability of immunosafety findings to human, tool development and interpretation of in vitro risk assessment for first-infusion reactions, innate or adaptive immunotox screening assays, MABEL approaches for entry-into-human/clinical study plans
Provide expert advice (incl. due diligences) and mechanistic workup of findings in pre-clinical and clinical studies
Ensure timely delivery and contribution to high quality study reports and safety documents as well as clear position on safety issues that arise during the evaluation of a drug candidate are expected
Who you are
You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point.
You have sound scientific practices, excellent interpersonal, leadership as well as written and oral communication skills that enable you to work effectively with colleagues at different sites and in external initiatives. In addition you have/are:
PhD or MD with at least 10 years experimental immunology experience post PhD/MD within industry
An excellent understanding of basic and current immunology and the ability to apply this knowledge to complex issues
A proven track record of publishing in peer reviewed journals
Excellent command of English
A reliable and self-motivated person with excellent interpersonal, leadership and presentation skills who can collaborate successfully across technical and organisational boundaries
Ideally experience in developing biologics, namely mAbs, peptides, new entities (e.g. fusion/bispecific molecules) and immune engaging molecules